تأثیر یک دوره تمرین مقاومتی بر سطح سرمی اینترلوکین 17 و اینترفرون بتادر زنان جوان مبتال به مولتیپل اسکلروزیس. (Persian)

Background and Objectives Cytokines play a major role in numerous diseases and are considered an important target for therapeutic interventions. Therefore, the present study aimed to assess the effect of a course of resistance training on the serum level of Interleukin-17 (IL-17) and Interferon-β (IFN-β) in young women with multiple sclerosis (MS). Subjects and Methods The present study was conducted based on a pre-test and posttest quasi-experimental design. A total of 30 women with MS within the age range of 30- 35 years were randomly selected and assigned to two groups: exercise (n=15) and control (n=15). Resistance exercises were performed for eight weeks and three sessions a week, each session lasting 60 min with an intensity of 60%-70% of heart rate reserve. Blood samples were taken before and after the training protocol with 12 hours of fasting, and the levels of IL-17 and IFN-β were measured using the ELISA method. Data were analyzed in SPSS software (version 220) using the covariance test. Results The results demonstrated that after eight hours of resistance training intervention, IL-17 level decreased significantly in the training group, while IFN-β showed a significant increase compared to the control group (P<0.05). Conclusion Since moderate-intensity resistance training decreased IL-17 and increased IFN-β in patients with MS, it seems that exercise intervention can be used to treat and prevent the progression of MS along with drug treatments. [ABSTRACT FROM AUTHOR]

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