Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53.
In: Proceedings of the National Academy of Sciences of the United States of America, Jg. 121 (2024-03-19), Heft 12, S. 1-79
academicJournal
Zugriff:
During metazoan development, how cell division and metabolic programs are coordinated with nutrient availability remains unclear. Here, we show that nutrient availability signaled by the neuronal cytokine, ILC-17.1, switches Caenorhabditis elegans development between reproductive growth and dormancy by controlling the activity of the tumor suppressor p53 ortholog, CEP-1. Specifically, upon food availability, ILC-17.1 signaling by amphid neurons promotes glucose utilization and suppresses CEP-1/p53 to allow growth. In the absence of ILC-17.1, CEP-1/p53 is activated, up-regulates cell-cycle inhibitors, decreases phosphofructokinase and cytochrome C expression, and causes larvae to arrest as stress-resistant, quiescent dauers. We propose a model whereby ILC-17.1 signaling links nutrient availability and energy metabolism to cell cycle progression through CEP-1/p53. These studies describe ancestral functions of IL-17 s and the p53 family of proteins and are relevant to our understanding of neuroimmune mechanisms in cancer. They also reveal a DNA damage-independent function of CEP-1/p53 in invertebrate development and support the existence of a previously undescribed C. elegans dauer pathway. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53.
|
---|---|
Autor/in / Beteiligte Person: | Godthi, Abhishiktha ; Min, Sehee ; Das, Srijit ; Cruz-Corchado, Johnny ; Deonarine, Andrew ; Misel-Wuchter, Kara ; Issuree, Priya D. ; Prahlad, Veena |
Zeitschrift: | Proceedings of the National Academy of Sciences of the United States of America, Jg. 121 (2024-03-19), Heft 12, S. 1-79 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0027-8424 (print) |
DOI: | 10.1073/pnas.2315248121 |
Schlagwort: |
|
Sonstiges: |
|