Interferons in Viral Infections.
In: Viruses (1999-4915), Jg. 16 (2024-03-01), Heft 3, S. 451-455
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Zugriff:
This document is a summary of a journal article titled "Interferons in Viral Infections." The article discusses the role of interferons (IFNs) in inhibiting viral replication in host cells by triggering innate immune responses. It explains how viral nucleic acids are recognized by cellular sensor proteins called pattern recognition receptors (PRRs), which activate downstream signaling cascades that induce the production of type-I IFNs and other proinflammatory cytokines. The article also includes a compilation of studies on interferon signaling during viral infection, covering topics such as the influence of IFNLR1 isoforms on cellular responses to interferons, the activation of interferon-stimulated genes (ISGs) in Varicella zoster virus infection, and the role of IRF3 and NF-κB in interferon production and antiviral activity. The review articles discuss the role of IFIT proteins in different pathologies, the involvement of STING in herpes simplex virus replication, and the transcriptional and non-transcriptional activation of IRF3 during viral infection. The conclusion highlights the importance of further research in understanding interferon production and signaling pathways and their potential for therapeutic applications. [Extracted from the article]
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Titel: |
Interferons in Viral Infections.
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Autor/in / Beteiligte Person: | Sengupta, Pracheta ; Chattopadhyay, Saurabh |
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Zeitschrift: | Viruses (1999-4915), Jg. 16 (2024-03-01), Heft 3, S. 451-455 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1999-4915 (print) |
DOI: | 10.3390/v16030451 |
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