Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.
In: Journal of Occupational Medicine & Toxicology, Jg. 19 (2024-04-04), Heft 1, S. 1-10
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Zugriff:
Background: Chronic obstructive pulmonary disease (COPD) affecting 334 million people in the world remains a major cause of morbidity and mortality. Proper diagnosis of COPD is still a challenge and largely solely based on spirometric criteria. We aimed to investigate the potential of nitrosative/oxidative stress and related metabolic biomarkers in exhaled breath condensate (EBC) to discriminate COPD patients. Methods: Three hundred three participants were randomly selected from a 15,000-transit worker cohort within the Respiratory disease Occupational Biomonitoring Collaborative Project (ROBoCoP). COPD was defined using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria as post-bronchodilator ratio of Forced Expiratory Volume in 1st second to Forced Vital Capacity < 0.7 in spirometry validated by an experienced pulmonologist. Discriminative power of biomarker profiles in EBC was analyzed using linear discriminant analyses. Results: Amongst 300 participants with validated spirometry, 50.3% were female, 52.3 years old in average, 36.0% were current smokers, 12.7% ex-smokers with mean tobacco exposure of 15.4 pack-years. Twenty-one participants (7.0%) were diagnosed as COPD, including 19 new diagnoses, 12 of which with a mild COPD stage (GOLD 1). Amongst 8 biomarkers measured in EBC, combination of 2 biomarkers, Lactate and Malondialdehyde (MDA) significantly discriminated COPD subjects from non-COPD, with a 71%-accuracy, area under the receiver curve of 0.78 (p-value < 0.001), and a negative predictive value of 96%. Conclusions: These findings support the potential of biomarkers in EBC, in particular lactate and MDA, to discriminate COPD patients even at a mild or moderate stage. These EBC biomarkers present a non-invasive and drugless technique, which can improve COPD diagnosis in the future. [ABSTRACT FROM AUTHOR]
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Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.
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Autor/in / Beteiligte Person: | Freund, Romain ; Sauvain, Jean‑Jacques ; Suarez, Guillaume ; Wild, Pascal ; Charreau, Thomas ; Debatisse, Amélie ; Sakthithasan, Kirushanthi ; Jouannique, Valérie ; Pralong, Jacques A. ; Guseva Canu, Irina |
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Zeitschrift: | Journal of Occupational Medicine & Toxicology, Jg. 19 (2024-04-04), Heft 1, S. 1-10 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1745-6673 (print) |
DOI: | 10.1186/s12995-024-00409-6 |
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