The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study.
In: International Breastfeeding Journal, Jg. 19 (2024-04-08), Heft 1, S. 1-11
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Zugriff:
Background: A lack of safety data on postpartum medication use presents a potential barrier to breastfeeding and may result in infant exposure to medications in breastmilk. The type and extent of medication use by lactating women requires investigation. Methods: Data were collected from the CHILD Cohort Study which enrolled pregnant women across Canada between 2008 and 2012. Participants completed questionnaires regarding medications and non-prescription medications used and breastfeeding status at 3, 6 and 12 months postpartum. Medications, along with self-reported reasons for medication use, were categorized by ontologies [hierarchical controlled vocabulary] as part of a large-scale curation effort to enable more robust investigations of reasons for medication use. Results: A total of 3542 mother-infant dyads were recruited to the CHILD study. Breastfeeding rates were 87.4%, 75.3%, 45.5% at 3, 6 and 12 months respectively. About 40% of women who were breastfeeding at 3 months used at least one prescription medication during the first three months postpartum; this proportion decreased over time to 29.5% % at 6 months and 32.8% at 12 months. The most commonly used prescription medication by breastfeeding women was domperidone at 3 months (9.0%, n = 229/2540) and 6 months (5.6%, n = 109/1948), and norethisterone at 12 months (4.1%, n = 48/1180). The vast majority of domperidone use by breastfeeding women (97.3%) was for lactation purposes which is off-label (signifying unapproved use of an approved medication). Non-prescription medications were more often used among breastfeeding than non-breastfeeding women (67.6% versus 48.9% at 3 months, p < 0.0001), The most commonly used non-prescription medications were multivitamins and Vitamin D at 3, 6 and 12 months postpartum. Conclusions: In Canada, medication use is common postpartum; 40% of breastfeeding women use prescription medications in the first 3 months postpartum. A diverse range of medications were used, with many women taking more than one prescription and non-prescription medicines. The most commonly used prescription medication by breastfeeding women were domperidone for off-label lactation support, signalling a need for more data on the efficacy of domperidone for this indication. This data should inform research priorities and communication strategies developed to optimize care during lactation. [ABSTRACT FROM AUTHOR]
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The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study.
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Autor/in / Beteiligte Person: | Soliman, Youstina ; Yakandawala, Uma ; Leong, Christine ; Garlock, Emma S. ; Brinkman, Fiona S.L. ; Winsor, Geoffrey L. ; Kozyrskyj, Anita L ; Mandhane, Piushkumar J ; Turvey, Stuart E. ; Moraes, Theo J. ; Subbarao, Padmaja ; Nickel, Nathan C. ; Thiessen, Kellie ; Azad, Meghan B ; Kelly, Lauren E |
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Zeitschrift: | International Breastfeeding Journal, Jg. 19 (2024-04-08), Heft 1, S. 1-11 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1746-4358 (print) |
DOI: | 10.1186/s13006-024-00628-x |
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