Lactate, histone lactylation and cancer hallmarks.
In: Expert Reviews in Molecular Medicine, Jg. 25 (2023), S. 1-8
academicJournal
Zugriff:
Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation. [ABSTRACT FROM AUTHOR]
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Lactate, histone lactylation and cancer hallmarks.
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Autor/in / Beteiligte Person: | Lv, Xinyu ; Lv, Yingying ; Dai, Xiaofeng |
Zeitschrift: | Expert Reviews in Molecular Medicine, Jg. 25 (2023), S. 1-8 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1462-3994 (print) |
DOI: | 10.1017/erm.2022.42 |
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