Different Sources of Fiber Intake and Risk of 17 Specific Cancers and All Cancers Combined: Prospective Study of 364,856 Participants in the UK Biobank.
In: American Journal of Epidemiology, Jg. 193 (2024-04-01), Heft 4, S. 660-672
academicJournal
Zugriff:
Inverse associations between dietary fiber (DF) and colorectal cancer risk are well-established. However, evidence is limited in relation to other cancer sites. This study, of 364,856 participants from the UK Biobank, aimed to evaluate the associations between total and source-specific partial DF and risk of 17 specific cancers and all cancers combined. Partial DF was derived from baseline touchscreen questionnaire data on cereal, bread, fruit, and vegetable intake. The outcomes were incident cancer at 17 sites and all cancers combined. Cox proportional hazards models were applied. Over a median 8.8-year follow-up period, 30,725 people were diagnosed with cancer. After adjusting for sociodemographic and lifestyle factors, those in the highest quintile of partial DF compared with the lowest quintile (<9.6 vs ≥19.1 g/day) had 10% lower risk of cancer overall, with the greatest risk reductions observed for cervical (hazard ratio (HR) = 0.33, 95% confidence interval (CI): 0.14; 0.82), esophageal (HR = 0.66, 95% CI: 0.52; 0.84), lung (HR = 0.67, 95% CI: 0.59; 0.76), bladder (HR = 0.72, 95% CI: 0.56; 0.91), and kidney (HR = 0.75, 95% CI: 0.61; 0.92) cancers. Associations between DF and lung cancer were observed only in current and former smokers. Higher DF intake, in particular cereal fiber and fruit and vegetable fiber, was associated with a lower risk of overall and multiple site-specific cancers. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Epidemiology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Different Sources of Fiber Intake and Risk of 17 Specific Cancers and All Cancers Combined: Prospective Study of 364,856 Participants in the UK Biobank.
|
---|---|
Autor/in / Beteiligte Person: | Parra-Soto, Solange ; Araya, Carolina ; Knight, Katrina ; Livingstone, Katherine M ; Malcomson, Fiona C ; Sharp, Linda ; Mathers, John C ; Ho, Frederick K ; Celis-Morales, Carlos ; Pell, Jill P |
Zeitschrift: | American Journal of Epidemiology, Jg. 193 (2024-04-01), Heft 4, S. 660-672 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0002-9262 (print) |
DOI: | 10.1093/aje/kwad202 |
Schlagwort: |
|
Sonstiges: |
|