Abnormalities in brain structure following childhood unpredictability: a mechanism underlying depressive and anxiety symptoms.
In: Psychological Medicine, Jg. 54 (2024-01-15), Heft 2, S. 299-307
academicJournal
Zugriff:
Background: Childhood adversity is associated with abnormalities in brain structure, but this association has not been tested for childhood unpredictability, one form of adversity. We studied whether abnormalities in gray matter volume (GMV) could be a mechanism linking childhood unpredictability and psychopathology, over and above the effect of childhood trauma. Methods: Participants were 158 right-handed healthy young adults (aged 17–28 years, M = 22.07, s.d. = 2.08; 66.46% female) who underwent structural magnetic resonance imaging measurements and provided retrospective reports of childhood unpredictability. The anxiety and depression subscales of the self-report Brief Symptom Inventory-53 were used to index psychopathology. Results: Whole-brain voxel-based morphometric analyses showed that after controlling for the effect of childhood trauma, childhood unpredictability was correlated with greater GMV in bilateral frontal pole, bilateral precuneus, bilateral postcentral gyrus, right hemisphere of fusiform, and lingual gyrus, and left hemisphere of ventrolateral prefrontal cortex as well as occipital gyrus. Greater GMV in bilateral frontal pole, bilateral precuneus, and bilateral postcentral gyrus mediated associations between unpredictability and symptoms of depression and anxiety. Conclusions: The findings suggest that childhood unpredictability could exact unique effects on neural development, over and above the effect of childhood trauma. These findings are relevant for understanding the occurrence of psychopathology following childhood unpredictability and have implications for intervention. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Abnormalities in brain structure following childhood unpredictability: a mechanism underlying depressive and anxiety symptoms.
|
---|---|
Autor/in / Beteiligte Person: | Wang, Zhengxinyue ; Cao, Xinyu ; Zheng, Xiaoyu ; Chen, Yuanyuan ; Zhu, Jianjun |
Zeitschrift: | Psychological Medicine, Jg. 54 (2024-01-15), Heft 2, S. 299-307 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0033-2917 (print) |
DOI: | 10.1017/S0033291723001526 |
Schlagwort: |
|
Sonstiges: |
|