Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis.
In: British Journal of Nutrition, Jg. 131 (2024-05-14), Heft 9, S. 1473-1487
Online
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Zugriff:
Vitamin D is a vital indicator of musculoskeletal health, as it plays an important role through the regulation of bone and mineral metabolism. This meta-analysis was performed to investigate the effects of vitamin D supplementation/fortification on bone turnover markers in women. All human randomised clinical trials reported changes in bone resorption markers (serum C-terminal telopeptide of type-I collagen (sCTX) and urinary type I collagen cross-linked N-telopeptide (uNTX)) or bone formation factors (osteocalcin (OC), bone alkaline phosphatase (BALP) and procollagen type-1 intact N-terminal propeptide (P1NP)) following vitamin D administration in women (aged ≥ 18 years) were considered. Mean differences (MD) and their respective 95 % CI were calculated based on fixed or random effects models according to the heterogeneity status. Subgroup analyses, meta-regression models, sensitivity analysis, risk of bias, publication bias and the quality of the included studies were also evaluated. We found that vitamin D supplementation had considerable effect on sCTX (MD: −0·038, n 22) and OC (MD: −0·610, n 24) with high heterogeneity and uNTX (MD: −8·188, n 6) without heterogeneity. Our results showed that age, sample size, dose, duration, baseline vitamin D level, study region and quality of studies might be sources of heterogeneity in this meta-analysis. Subgroup analysis also revealed significant reductions in P1NP level in dose less than 600 μg/d and larger study sample size (>100 participants). Moreover, no significant change was found in BALP level. Vitamin D supplementation/fortification significantly reduced bone resorption markers in women. However, results were inconsistent for bone formation markers. [ABSTRACT FROM AUTHOR]
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Titel: |
Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis.
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Autor/in / Beteiligte Person: | Nasimi, Nasrin ; Jamshidi, Sanaz ; Askari, Aida ; Zolfaghari, Nazanin ; Sadeghi, Erfan ; Nouri, Mehran ; Bellissimo, Nick ; Faghih, Shiva |
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Zeitschrift: | British Journal of Nutrition, Jg. 131 (2024-05-14), Heft 9, S. 1473-1487 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0007-1145 (print) |
DOI: | 10.1017/S0007114524000060 |
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