Seoul National University Researchers Discuss Findings in Glaucoma (Exploring the role of apolipoprotein E gene promoter polymorphisms in susceptibility to normal-tension glaucoma in a Korean population).

A study conducted by researchers at Seoul National University explores the role of apolipoprotein E (APOE) gene promoter polymorphisms in susceptibility to normal-tension glaucoma (NTG) in a Korean population. The study analyzed a cohort of 178 NTG patients and 32,858 individuals from the Korean Genome and Epidemiology Study (KoGES) cohort. The researchers found that a specific SNP (rs769446) in the APOE gene promoter exhibited significant differences between NTG cases and controls, with the minor allele C of rs769446 acting as a protective factor against NTG. The study suggests that further research is needed to understand how APOE promoter SNPs contribute to NTG pathogenesis. [Extracted from the article]

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