Reports from Guizhou Medical University Highlight Recent Research in Apoptosis (A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis).
In: Drug Week, 2024-05-17, S. 1878-1878
serialPeriodical
Zugriff:
A recent report from Guizhou Medical University in China discusses the potential of a newly synthesized indole derivative called LWX-473 in overcoming glucocorticoid resistance in lymphoid malignancies. Glucocorticoids are commonly used in chemotherapy for lymphoid malignancies, but the development of resistance limits their effectiveness. The study found that LWX-473, alone or in combination with the glucocorticoid Dexamethasone, significantly improved cell apoptosis and cell cycle arrest in Jurkat cells. LWX-473 demonstrated the ability to restore sensitivity to Dexamethasone by modulating the mitochondrial membrane potential, activating the expression of the glucocorticoid receptor, and inhibiting key molecules in the JAK/STAT signaling pathway. The findings suggest that LWX-473 could be a potential therapeutic agent for overcoming glucocorticoid resistance in lymphoid malignancies. [Extracted from the article]
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Reports from Guizhou Medical University Highlight Recent Research in Apoptosis (A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis).
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Zeitschrift: | Drug Week, 2024-05-17, S. 1878-1878 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6440 (print) |
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