RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1.
In: Zika & Mosquito Week, 2024-05-13, S. 4186-4186
serialPeriodical
Zugriff:
A preprint abstract from biorxiv.org discusses the role of RIFINs, proteins displayed on the surface of Plasmodium falciparum-infected red blood cells, in the interaction between natural killer (NK) cells and malaria-infected cells. The study finds that certain RIFINs can bind to inhibitory immune receptors, reducing NK cell activation and parasite killing. Additionally, the researchers identify a clade of RIFINs that bind to the inhibitory immune receptor KIR2DL1 more strongly than its host ligand, and show that these RIFINs can also bind to the activating immune receptor KIR2DS1, leading to NK cell activation. This research sheds light on the evolutionary battle between pathogens and hosts, suggesting that activating immune receptors may have evolved to detect and clear malaria-infected red blood cells. [Extracted from the article]
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RIFINs displayed on malaria-infected erythrocytes bind both KIR2DL1 and KIR2DS1.
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Zeitschrift: | Zika & Mosquito Week, 2024-05-13, S. 4186-4186 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
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