Standardizing protein corona characterization in nanomedicine: a multi-center study to enhance reproducibility and data homogeneity.
In: Health & Medicine Week, 2024-05-17, S. 2480-2480
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Zugriff:
A recent study has found significant variability in the characterization of protein corona, which is the layer of proteins that forms around nanoparticles in nanomedicine. The study identified variations in sample preparation protocols, liquid chromatography mass spectrometry workflows, and raw data processing as the main sources of heterogeneity in protein corona composition. To address this issue, the researchers developed standardized protocols and distributed identical protein corona samples to multiple proteomics centers. They also evaluated the impact of using similar mass spectrometry instruments and standardizing database search parameters on data consistency. The findings suggest that streamlining these processes can improve the reliability and consistency of nanomedicine-based diagnostics and therapeutics. [Extracted from the article]
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Standardizing protein corona characterization in nanomedicine: a multi-center study to enhance reproducibility and data homogeneity.
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Zeitschrift: | Health & Medicine Week, 2024-05-17, S. 2480-2480 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6459 (print) |
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