Characterization of Perioperative Serotonin in Patients Undergoing Orthotopic Liver Transplantation.
In: Journal of Clinical Medicine, Jg. 13 (2024-05-01), Heft 9, S. 2640-2650
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Zugriff:
Background: Platelets were shown to be relevant for liver regeneration. In particular, platelet-stored serotonin (5-HT) proved to be a pro-regenerative factor in this process. The present study aimed to investigate the perioperative course of 5-HT and evaluate associations with patient and graft outcomes after othotopic liver transplantation (OLT). Methods: 5-HT was quantified in plasma and serum of 44 OLT recipients perioperatively, and in their respective donors. Olthoff's criteria for early allograft dysfunction (EAD) were used to evaluate postoperative outcomes. Results: Patients with higher donor intra-platelet 5-HT per platelet (IP 5-HT PP) values had significantly lower postoperative transaminases (ASAT POD1: p = 0.006, ASAT POD5: p = 0.006, ASAT POD10: p = 0.02, ALAT POD1: p = 0.034, ALAT POD5: p = 0.017, ALAT POD10: p = 0.04). No significant differences were seen between postoperative 5-HT values and the occurrence of EAD. A tendency was measured that donor IP 5-HT PP is lower in donor-recipient pairs that developed EAD (p = 0.07). Conclusions: Donor IP 5-HT PP might be linked to the postoperative development of EAD after OLT, as higher donor levels are correlated with a more favorable postoperative course of transaminases. Further studies with larger cohorts are needed to validate these findings. [ABSTRACT FROM AUTHOR]
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Titel: |
Characterization of Perioperative Serotonin in Patients Undergoing Orthotopic Liver Transplantation.
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Autor/in / Beteiligte Person: | Zott, Tobias ; Pereyra, David ; Kersten, Isabelle ; Ortner, Max ; Hüpper, Maria Noelle ; Starlinger, Patrick ; Berlakovich, Gabriela A. ; Silberhumer, Gerd R. |
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Zeitschrift: | Journal of Clinical Medicine, Jg. 13 (2024-05-01), Heft 9, S. 2640-2650 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2077-0383 (print) |
DOI: | 10.3390/jcm13092640 |
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