A Silent Outbreak of Hepatitis E Virus (HEV) Infection or FalsePositive Reaction of Anti-HEV IgM after COVID-19 Vaccination? Epidemiological Investigation of an Outbreak in a Korean Factory Complex in 2022.
In: Gut & Liver, Jg. 18 (2024-05-01), Heft 3, S. 531-538
Online
academicJournal
Zugriff:
Background/Aims: To investigate a reported outbreak of presumed hepatitis E virus (HEV) infection in a Korean food manufacturing facility and to explore the association between anti-HEV immunoglobulin M (IgM) positivity and coronavirus disease 2019 (COVID-19) infection or vaccination. Methods: Twenty-four cases of anti-HEV IgM positivity were reported among 646 workers at the facility in 2022. An epidemiological investigation was conducted, comprising HEV-RNA testing of blood and environmental samples, analysis of group meal records, and an association between anti-HEV IgM positivity and confirmed COVID-19 infection or vaccination. Results: All 24 patients were asymptomatic, with cases spread sporadically across the facility. HEV RNA was not detected in the serum or environmental samples. Four out of 340 meals (1.2%) showed a significantly higher proportion of anti-HEV positivity in each meal intake group than in the non-intake group on certain days. Although the cumulative rate of COVID-19 infection showed no difference, the anti-HEV IgM positive group showed significantly higher proportions of >2 doses of COVID-19 vaccination (83.3% vs 48.7%, p=0.021), vaccination within 90 days (45.8% vs 19.7%, p=0.008), and having the Moderna vaccine administered as the last vaccine (75.0% vs 14.5%, p<0.001) than those of the anti-HEV negative group. In four multivariable models, three or more COVID-19 vaccinations and the Moderna vaccine as the last vaccine were consistently associated with anti-HEV IgM positivity, while the specific day group meal intake was also a significant factor. Conclusions: This epidemiological investigation showed that anti-HEV IgM positivity may occur as a false-positive result related to COVID-vaccination over three times and use of the Moderna vaccine, although a portion of true HEV infection may not be excluded. [ABSTRACT FROM AUTHOR]
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A Silent Outbreak of Hepatitis E Virus (HEV) Infection or FalsePositive Reaction of Anti-HEV IgM after COVID-19 Vaccination? Epidemiological Investigation of an Outbreak in a Korean Factory Complex in 2022.
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Autor/in / Beteiligte Person: | Oh, Jeonghyeon ; Gwang Hyeon Choi ; Chang, Yeonhwa ; Kim, Jina ; Park, Kunhee ; Yeom, Hansol ; Seo, Soonryu ; Gwack, Jin ; Jeong, Sook-Hyang |
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Zeitschrift: | Gut & Liver, Jg. 18 (2024-05-01), Heft 3, S. 531-538 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1976-2283 (print) |
DOI: | 10.5009/gnl230098 |
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