Metal- and photocatalyst-free three-component strategy to prepare benzylalcohol-, aldehydesubstituted BCP building blocks.
In: Green Chemistry, Jg. 26 (2024-05-07), Heft 9, S. 5531-5537
academicJournal
Zugriff:
Bicyclo[1.1.1]pentanes (BCPs), which can serve as bioisosteres of para-disubstituted benzene rings, have emerged as useful bioactive scaffolds in drug discovery research. Herein, we report a one-step, light-promoted, three-component radical-coupling method for rapidly generating difunctionalized benzylalcohol-, aldehyde-substituted BCPs from aryl aldehydes, ethers, and [1.1.1]propellane. The method, which does not require metals or photocatalysts, features a broad substrate scope (58 examples) and excellent functional group tolerance. Furthermore, this protocol can be scaled up to the gram-level. Remarkably, these transformations are external-oxidant-free, thus exemplifying an environmentally friendly and practical synthetic strategy. [ABSTRACT FROM AUTHOR]
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Titel: |
Metal- and photocatalyst-free three-component strategy to prepare benzylalcohol-, aldehydesubstituted BCP building blocks.
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Autor/in / Beteiligte Person: | Li, Fei ; Liao, Huijuan ; Dong, Jianyang ; Xiong, Weikang ; Yan, Yonggang ; Li, Gang ; Xue, Dong |
Zeitschrift: | Green Chemistry, Jg. 26 (2024-05-07), Heft 9, S. 5531-5537 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1463-9262 (print) |
DOI: | 10.1039/d4gc01015a |
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