اثرات هورمون تستوسترون بر روی عملکردهای شناختی و رفتارهای شبه اضطرابی در مدل حیوانی همدردی. (Persian)
In: Knowledge & Health / Dānish va Tandurustī, Jg. 18 (2023-10-01), Heft 4, S. 12-20
academicJournal
Zugriff:
Introduction: Empathy is one of the special cognitive functions that play an important role in the evolution of social behaviors and the formation of social memory. Testosterone have neuroprotective effects against cognitive and behavioral disorders and may be very important in the development of social and cognitive behaviors. Therefore, this study investigated the role of testosterone hormone in social behaviors, novel object recognition memory, and anxiety-like behaviors in a rat model of empathic pain. Methods: In this study, 32 gonadectomized male rats were divided into four groups: control, pain, observer + vehicle (castor oil), and observer + testosterone. The emotional pain experienced by a family member who received five formalin injections was socially transferred to the observing rat within the same family through observation. The observation groups received vehicle or testosterone before observing the suffering of mice. Then, social memory, novel object recognition memory, and anxiety-like behaviors were tested. Results: The results indicated that in the pain group, both social memory and novel object recognition memory were impaired compared to the control group, and anxiety-like behaviors were increased. Conversely, testosterone injection partially improved social memory and novel object recognition memory deficits, and reduced anxiety-like behaviors compared with the observer+vehicle group. Conclusion: In conclusion, empathy causes anxious behavior and social and novel object recognition memory impairments. Furthermore, testosterone hormones can play a protective role against cognitive and behavioral damages caused by empathy in rats. [ABSTRACT FROM AUTHOR]
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Titel: |
اثرات هورمون تستوسترون بر روی عملکردهای شناختی و رفتارهای شبه اضطرابی در مدل حیوانی همدردی. (Persian)
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Autor/in / Beteiligte Person: | طالبی, علی ; فاطمه رحیمی شور م ; صبا نیکنام فر ; خدامرادی, مهدی ; سیده معصومه سید ح ; رفایی, راحله ; شعبانی, حسین ; مقربیان, ناصر ; قزوینی, حامد |
Zeitschrift: | Knowledge & Health / Dānish va Tandurustī, Jg. 18 (2023-10-01), Heft 4, S. 12-20 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1735-577X (print) |
DOI: | 10.22100/jkh.v18i4.3169 |
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