Modulating anti-inflammatory and anticancer properties by designing a family of metal-complexes based on 5-nitropicolinic acid.
In: Dalton Transactions: An International Journal of Inorganic Chemistry, Jg. 53 (2024-06-07), Heft 21, S. 8988-9000
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Zugriff:
A new family of six complexes based on 5-nitropicolinic acid (5-npic) and transition metals has been obtained: [M(5-npic) 2 ] n (M II = Mn (1) and Cd (2)), [Cu(5-npic) 2 ] n (3), and [M(5-npic) 2 (H 2 O) 2 ] (M II = Co (4), Ni (5), and Zn (6)), which display 1D, 2D, and mononuclear structures, respectively, thanks to different coordination modes of 5-npic. After their physicochemical characterization by single-crystal X-ray diffractio (SCXRD), elemental analyses (EA), and spectroscopic techniques, quantum chemical calculations using Time-Dependent Density Functional Theory (TD-DFT) were performed to further study the luminescence properties of compounds 2 and 6. The potential anticancer activity of all complexes was tested against three tumor cell lines, B16-F10, HT29, and HepG2, which are models widely used for studying melanoma, colon cancer, and liver cancer, respectively. The best results were found for compounds 2 and 4 against B16-F10 (IC 50 = 26.94 and 45.10 µg mL -1 , respectively). In addition, anti-inflammatory studies using RAW 264.7 cells exhibited promising activity for 2, 3, and 6 (IC 50 NO = 5.38, 24.10, and 17.63 µg mL -1 , respectively). This multidisciplinary study points to complex 2, based on Cd II , as a promising anticancer and anti-inflammatory material. [ABSTRACT FROM AUTHOR]
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Titel: |
Modulating anti-inflammatory and anticancer properties by designing a family of metal-complexes based on 5-nitropicolinic acid.
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Autor/in / Beteiligte Person: | García-García, Amalia ; Medina-O'donnell, Marta ; Rojas, Sara ; Cano-Morenilla, Mariola ; Morales, Juan ; Quesada-Moreno, María Mar ; Sainz, Juan ; Vitorica-Yrezabal, Iñigo J. ; Rodríguez-Diéguez, Antonio ; Navarro, Amparo ; Reyes-Zurita, Fernando J. |
Zeitschrift: | Dalton Transactions: An International Journal of Inorganic Chemistry, Jg. 53 (2024-06-07), Heft 21, S. 8988-9000 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1477-9226 (print) |
DOI: | 10.1039/d4dt00265b |
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