Long-term clinical outcomes of [<superscript>177</superscript>Lu]Lu-DOTATATE in patients with metastatic neuroendocrine tumors.
In: Frontiers in Oncology, 2024-05-30, S. 1-6
Online
academicJournal
Zugriff:
The incidence of gastroenteropancreatic neuroendocrine tumors has been rising and these tumors are usually only diagnosed at a metastatic stage. Present first line treatments include somatostatin analogs, targeted therapies and peptide receptor radionuclide therapy. The Lutetium-177 [ 177 Lu] based radiotracer [ 177 Lu] Lu-DOTATATE has only been approved as first-line treatment of metastatic midgut NETs however its efficacy as a third line or above treatment in patients with non ileal primaries has not been tested. In our study, we identified 25 patients with histologically confirmed well-differentiated metastatic neuroendocrine tumors and administered [ 177 Lu]Lu-DOTATATE as a second line, third line and fourth line treatment. Our study demonstrated a notable response in patients with non-ileal primaries and heavily pretreated disease, warranting further studies for additional cycles of treatment. [ABSTRACT FROM AUTHOR]
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Long-term clinical outcomes of [<superscript>177</superscript>Lu]Lu-DOTATATE in patients with metastatic neuroendocrine tumors.
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Autor/in / Beteiligte Person: | Iqbal, Sabah ; Zhuang, Eric ; Raj, Moses ; Bahary, Nathan ; Monga, Dulabh K. |
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Zeitschrift: | Frontiers in Oncology, 2024-05-30, S. 1-6 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2234-943X (print) |
DOI: | 10.3389/fonc.2024.1393317 |
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