A Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories.
In: Journal of Alzheimer's Disease, Jg. 99 (2024-06-01), Heft 3, S. 843-856
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Zugriff:
Background: There is a common agreement that Alzheimers disease (AD) is inherently complex; otherwise, a general disagreement remains on its etiological underpinning, with numerous alternative hypotheses having been proposed. Objective: To perform a scoping review of original manuscripts describing hypotheses and theories of AD published in the past decades. Results: We reviewed 131 original manuscripts that fulfilled our inclusion criteria out of more than 13,807 references extracted from open databases. Each entry was characterized as having a single or multifactorial focus and assigned to one of 15 theoretical groupings. Impact was tracked using open citation tools. Results: Three stages can be discerned in terms of hypotheses generation, with three quarter of studies proposing a hypothesis characterized as being single-focus. The most important theoretical groupings were the Amyloid group, followed by Metabolism and Mitochondrial dysfunction, then Infections and Cerebrovascular. Lately, evidence towards Genetics and especially Gut/Brain interactions came to the fore. Conclusions: When viewed together, these multi-faceted reports reinforce the notion that AD affects multiple sub-cellular, cellular, anatomical, and physiological systems at the same time but at varying degree between individuals. The challenge of providing a comprehensive view of all systems and their interactions remains, alongside ways to manage this inherent complexity. [ABSTRACT FROM AUTHOR]
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Titel: |
A Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories.
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Autor/in / Beteiligte Person: | Duchesne, Simon ; Rousseau, Louis-Simon ; Belzile-Marsolais, Florence ; Welch, Laurie-Ann ; Cournoyer, Béatrice ; Arseneau, Marianne ; Lapierre, Véronick ; Poulin, Sara-Maude ; Potvin, Olivier ; Hudon, Carol |
Zeitschrift: | Journal of Alzheimer's Disease, Jg. 99 (2024-06-01), Heft 3, S. 843-856 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1387-2877 (print) |
DOI: | 10.3233/JAD-230772 |
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