Research from University of Idaho in Malaria Provides New Insights (Basophil-Derived IL-4 and IL-13 Protect Intestinal Barrier Integrity and Control Bacterial Translocation during Malaria).

A recent report from the University of Idaho discusses the role of basophils in regulating various aspects of malaria. The researchers focused on the cytokines IL-4 and IL-13, which are produced by activated basophils. By studying mice with basophils depleted of IL-4 and IL-13, the researchers found that these cytokines play a crucial role in protecting the integrity of the intestinal barrier during malaria infection. They also found that basophil-derived IL-4 and IL-13 do not contribute to parasite transmission, but instead control mast cell activation and prevent infection-induced intestinal barrier damage and bacteremia. This research provides new insights into the immune response to malaria and the role of basophils in this process. [Extracted from the article]

Copyright of Zika & Mosquito Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)