Comparison of metformin, myoinositol and metformin-myoinositol combined treatments for polycystic ovary syndrome.
In: Turkish Journal of Obstetrics & Gynecology, Jg. 21 (2024-06-01), Heft 2, S. 78-84
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Zugriff:
Objective: The objective of this study was to assess the effectiveness of myoinositol (4 g myoinositol + 400 mcg folic acid/day) compared with metformin (average 1700 mg/day), as well as the combined efficacy of both treatments in managing insulin-resistant polycystic ovary syndrome (PCOS) among women. Materials and Methods: We retrospectively analyzed the records of 68 reproductive-age PCOS patients with insulin resistance over a 3-month period. Oral glucose tolerance tests (OGTT) (75 gr) were conducted to measure glucose levels at 0 and 120 min. Moreover, changes in prolactin, thyroid stimulating hormone, high-density lipoprotein, low-density lipoprotein, triglyceride levels, total cholesterol, follicle-stimulating hormone, luteinizing hormone, total testosterone, free testosterone, and dehydroepiandrosterone sulfate (DHEA-S) levels were evaluated pre- and post-treatment over a 3-month period. Results: Statistically significant improvements were observed in menstrual regularity, body mass index (BMI), modified Ferriman Gallwey scores, OGTT glucose levels at 0 and 120 min, total testosterone, free testosterone, and DHEA-S levels across all groups (p<0.005). Conclusion: No significant variances were observed in terms of BMI, modified Ferriman Gallwey scores, or androgen levels across the three treatment cohorts. The combination of myoinositol and metformin did not confer additional benefits compared with either treatment alone. [ABSTRACT FROM AUTHOR]
Amaç: Bu çalışmada, polikistik over sendromlu (PCOS) kadınlarda insülin direnci olanlarda myoinositol tedavisinin (günde 4 g myoinositol + 400 mcg folik asit) metformin (ortalama 1700 mg/gün) ile karşılaştırılması ve bu iki tedavinin kombinasyonunun etkinliğinin incelenmesi amaçlanmıştır. Gereç ve Yöntemler: Üreme çağındaki 68 insülin direnci olan PCOS hastasının 3 aylık hasta kayıtları incelenmiştir. Oral glikoz tolerans testleri (OGTT) (75 gr) 0 ve 120 dakikada glikoz düzeylerini, prolaktin, tiroid uyarıcı hormon, yüksek yoğunluklu lipoprotein, düşük yoğunluklu lipoprotein, trigliserid, total kolesterol, folikül stimüle edici hormon, luteinizan hormon, total testosteron, serbest testosteron, dehidroepiandrosteron sülfat (DHEA-S) düzeylerini ölçülmüş ve tedavinin ardından 3 ay sonra değerlerle karşılaştırılmıştır Bulgular: Tüm gruplarda adet düzeni, vücut kitle indeksi (VKİ), modifiye Ferriman Gallwey skorları, OGTT'nin 0. ve 120. dakikadaki glikoz düzeyleri, total testosteron, serbest testosteron, DHEA-S düzeylerinde istatistiksel olarak anlamlı bir iyileşme gözlenmiştir (p<0,005). Sonuç: VKİ, modifiye Ferriman Gallwey skorları ve azalan androjen düzeyleri açısından üç grup arasında fark bulunmamıştır. Myoinositolün metformin ile kombinasyonu, metformin veya yalnızca myoinositol kadar fayda sağlamamıştır. [ABSTRACT FROM AUTHOR]
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Titel: |
Comparison of metformin, myoinositol and metformin-myoinositol combined treatments for polycystic ovary syndrome.
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Autor/in / Beteiligte Person: | Karadağ, Ceyda ; Sakinci, Mehmet ; Birge, Özer ; Bakır, Mehmet Sait ; Karadağ, Burak ; Sağnıç, Saliha |
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Zeitschrift: | Turkish Journal of Obstetrics & Gynecology, Jg. 21 (2024-06-01), Heft 2, S. 78-84 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 2149-9322 (print) |
DOI: | 10.4274/tjod.galenos.2024.21456 |
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