Emerging role of Mcl-1 in actively counteracting BH3-only proteins in apoptosis.
In: Cell Death & Differentiation, Jg. 13 (2006-08-01), Heft 8, S. 1263-1267
Online
academicJournal
Zugriff:
The article discusses on the functions of Mcl-1 one of the antiapoptopic members, in antagonizing BH3 only proteins, the essential initiators of apoptopic cell death. Mcl-1 functions acts as a regulator in the apoptosis signalling which leads to the activation of mitochondrial pathway. It was recorded to interact directly with BH3-only proteins and to inhibit their induction of cytochrome c release in isolated mitochondria and apoptosis. BH3-only proteins is attacked more than Bcl-2 by the Mcl-1.
Titel: |
Emerging role of Mcl-1 in actively counteracting BH3-only proteins in apoptosis.
|
---|---|
Autor/in / Beteiligte Person: | Zhuang, J. ; Brady, H. J. M. |
Link: | |
Zeitschrift: | Cell Death & Differentiation, Jg. 13 (2006-08-01), Heft 8, S. 1263-1267 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 1350-9047 (print) |
DOI: | 10.1038/sj.cdd.4401952 |
Schlagwort: |
|
Sonstiges: |
|