The lactate:pyruvate ratio following open cardiac surgery in children.
In: Intensive Care Medicine, Jg. 33 (2007-05-01), Heft 5, S. 822-829
Online
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Zugriff:
Objective: To explore the relationship between lactate:pyruvate ratio, hyperlactataemia, metabolic acidosis, and morbidity. Design and Setting: Prospective observational study in the paediatric intensive care unit (PICU) of a university hospital. Patients: Ninety-seven children after open cardiac surgery. Most children (94%) fell into low-moderate operative risk categories; observed PICU mortality was 1%. Interventions: Blood was sampled on admission for acid-base analysis, lactate, and pyruvate. Metabolic acidosis was defined as standard bicarbonate lower than 22 mmol/l, raised lactate as higher than 2 mmol/l, and raised lactate:pyruvate ratio as higher than 20. Measurements and Results: Median cardiopulmonary bypass and aortic cross-clamp times were 80 and 46 min. Metabolic acidosis occurred in 74%, hyperlactataemia in 42%, and raised lactate:pyruvate ratio in 45% of children. In multivariate analysis lactate:pyruvate ratio increased by 6.4 in children receiving epinephrine infusion and by 0.4 per 10 min of aortic cross-clamp. Duration of inotropic support increased by 0.29 days, ventilatory support by 0.27 days, and PICU stay by 0.42 days, for each 1 mmol/l increase in lactate. Neither standard bicarbonate nor lactate:pyruvate ratio were independently associated with prolongation of PICU support. Conclusions: Elevated lactate:pyruvate ratio was common in children with mild metabolic acidosis and low PICU mortality. Hyperlactataemia, but not elevated lactate:pyruvate ratio or metabolic acidosis, was associated with prolongation of PICU support. Routine measurement of lactate:pyruvate ratio is not warranted for children in low-moderate operative risk categories. [ABSTRACT FROM AUTHOR]
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Titel: |
The lactate:pyruvate ratio following open cardiac surgery in children.
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Autor/in / Beteiligte Person: | Hatherill, Mark ; Salie, Shamiel ; Waggie, Zainab ; Lawrenson, John ; Hewitson, John ; Reynolds, Louis ; Argent, Andrew |
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Zeitschrift: | Intensive Care Medicine, Jg. 33 (2007-05-01), Heft 5, S. 822-829 |
Veröffentlichung: | 2007 |
Medientyp: | academicJournal |
ISSN: | 0342-4642 (print) |
DOI: | 10.1007/s00134-007-0593-3 |
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