Perspectives in Understanding the Role of Human 17β-Hydroxysteroid Dehydrogenases in Health and Disease.
In: Annals of the New York Academy of Sciences, Jg. 1155 (2009-02-26), S. 15-24
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Zugriff:
Steroid signaling involves specific receptors that mediate genomic effects and many further proteins responsible for fast nongenomic activities. Metabolism at the position 17 of the steroid scaffold plays a pivotal role in the final regulation of the biological potency of steroid hormones. Enzymes responsible for that, the 17β-hydroxysteroid dehydrogenases (17β-HSD), act as carbonyl reductases and require cofactors for their catalytic activity. There is a substantial amount of evidence that human 17β-HSDs are as well involved in the metabolic pathways of retinoids and fatty acid beyond that which has so far been anticipated. At present fourteen 17β-HSDs have been annotated and characterized, and more might follow. Many of 17β-HSDs have been shown to be involved in the pathogenesis of human disorders and are targets for therapeutic intervention. Strategies on deciphering the physiological role of the 17β-HSD and the genetic predisposition for associated diseases will be presented involving analyses of animal models. [ABSTRACT FROM AUTHOR]
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Perspectives in Understanding the Role of Human 17β-Hydroxysteroid Dehydrogenases in Health and Disease.
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Autor/in / Beteiligte Person: | Meier, Marc ; Möller, Gabriele ; Adamski, Jerzy |
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Zeitschrift: | Annals of the New York Academy of Sciences, Jg. 1155 (2009-02-26), S. 15-24 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0077-8923 (print) |
DOI: | 10.1111/j.1749-6632.2009.03702.x |
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