The effect of granulocyte colony-stimulating factor (G-CSF) on the activity of granulocyte enzymes in children with cancer who developed neutropenia after chemotherapy.
In: Advances in Medical Sciences (De Gruyter Open), Jg. 53 (2008-12-01), Heft 2, S. 278-282
Online
academicJournal
Zugriff:
Purpose: G-CSF is a cytokine that stimulates the proliferation and maturation of granulocyte precursor cells. The results of in vitro and in vivo investigations conducted on animal models revealed that this cytokine influences the functions of mature granulocytes increasing the activities of the granulocyte enzymes participating in phagocytosis. Material and methods: The investigation was conducted on a group of 26 children (age: 1.5 - 17 years) with cancer who developed neutropenia after chemotherapy and were treated with G-CSF. The control group included 29 healthy children (age: 5 -17 years). The heparinized blood samples were taken before the injection of the stimulator (time 0) and after the 2nd and 5th injection of G-CSF (on day 3 and 6). Activities of granulocyte enzymes involved in the process of phagocytosis (myeloperoxidase, acid and alkaline phosphatase and esterase) in blood smears were evaluated. Results: It has been found that G-CSF affects the activity of granulocyte enzymes by the normalization of decreased values of myeloperoxidase, acid phosphate and increasing the normal values of alkaline phosphate activity. The enzyme activities increased during the following days of treatment. Conclusion: Based on the obtained results, we can conclude that G-CSF activates the formation of fully competent granulocytes in cytostatic-treated children with various neoplastic diseases. [ABSTRACT FROM AUTHOR]
Copyright of Advances in Medical Sciences (De Gruyter Open) is the property of Sciendo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
The effect of granulocyte colony-stimulating factor (G-CSF) on the activity of granulocyte enzymes in children with cancer who developed neutropenia after chemotherapy.
|
---|---|
Autor/in / Beteiligte Person: | Czygier, M. ; Dakowicz, Ł ; Szmitkowski, M. |
Link: | |
Zeitschrift: | Advances in Medical Sciences (De Gruyter Open), Jg. 53 (2008-12-01), Heft 2, S. 278-282 |
Veröffentlichung: | 2008 |
Medientyp: | academicJournal |
ISSN: | 1896-1126 (print) |
DOI: | 10.2478/v10039-008-0018-8 |
Schlagwort: |
|
Sonstiges: |
|