A randomized, open labeled, comparative study to assess the efficacy and safety of controller medications as add on to inhaled corticosteroid and long-acting ß2 agonist in the treatment of moderate-to-severe persistent asthma.
In: Journal of Postgraduate Medicine, Jg. 56 (2010-10-01), Heft 4, S. 270-274
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Zugriff:
Background: The goal of asthma therapy is to achieve clinical control and near normal lung functions. Many patients with persistent asthma fail to achieve this goal with a single controller medication add on to a inhaled corticosteroid. We have checked whether another controller medication add on to inhaled corticosteroid and long-acting β 2 agonist helps in achieving the asthma goal or not. Objectives: To identify the effect of controller medication add on to inhaled corticosteroid and the long-acting β 2 agonist on the clinical symptom, lung function, and compliance in patients with asthma. Materials and Methods: We conducted a randomized, open-labeled, comparative trial in 50 participants with moderate-to-severe persistent asthma. The study duration was of 10 weeks. During the first two weeks of the run-in period all the participants received a dry powder inhaler drug delivery of budesonide (400 mcg/day) and formoterol (12 mcg/day) combination. At the end of the run-in period the participants were randomly allocated into three groups: group A (n = 16) received oral montelukast (10 mg/day); group B (n = 17) received oral doxophylline (400 mg/day), and group C (n = 17) received inhaled budesonide (400 mcg) as add on to the above-mentioned drugs of the run-in period. The primary outcome was improvement in forced expiratory volume at 1 second (FEV1). Results: All the participants of the three groups had significant improvement in FEV1 (P < 0.001) and asthma symptoms at the end of 10 weeks. The mean increase in FEV 1 (% of predicted) from the baseline, in groups A, B, and C was: 24.6; 21.33, and 19.86%, respectively. Conclusions: All add on controller medications helped, with a significant improvement of lung functions and asthma symptoms. [ABSTRACT FROM AUTHOR]
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Titel: |
A randomized, open labeled, comparative study to assess the efficacy and safety of controller medications as add on to inhaled corticosteroid and long-acting ß2 agonist in the treatment of moderate-to-severe persistent asthma.
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Autor/in / Beteiligte Person: | Patel, Y. A. ; Patel, P. ; Bavadia, H. ; Dave, J. ; Tripathi, C. B. |
Zeitschrift: | Journal of Postgraduate Medicine, Jg. 56 (2010-10-01), Heft 4, S. 270-274 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 0022-3859 (print) |
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