A Tomato Lycopene Complex Protects the Kidney From Cisplatin-Induced Injury via Affecting Oxidative Stress as Well as Bax, Bcl-2, and HSPs Expression.
In: Nutrition & Cancer, Jg. 63 (2011-04-01), Heft 3, S. 427-434
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Zugriff:
Cisplatin-induced nephrotoxicity is related to an increase in oxidative stress in the kidney. Lycopene, a carotenoid found in tomatoes, is a potent dietary antioxidant. In the present study, we investigated the effect of the tomato lycopene complex against cisplatin-induced lipid peroxidation and nephrotoxicity in rats. Male Wistar rats (n = 28, 8 wk old, between 200-215 g) were divided into 4 groups: (a) control, (b) tomato lycopene complex (6 mg/kg, daily; consisting of 6% lycopene, 1.5% tocopherols, 1% phytoene and phytofluene, and 0.2% β-carotene), (c) cisplatin (7 mg/kg i.p., single dose), and (d) cisplatin + tomato lycopene complex. Cisplatin administration increased serum urea-N (171 vs. 37 mg/dl) and creatinine (1.80 vs. 0.42 mg/dl) and decreased body weight in comparison with the control rats (P < 0.001). Serum creatinine and urea-N levels were lower in rats treated with tomato lycopene complex + cisplatin compared with rats treated with cisplatin alone (P < 0.001). The renal tissue from the cisplatin-treated rats had greater malondialdehyde (MDA; 172 vs. 93 nmol/g) and 8-isoprostane levels (1810 vs. 610 pg/g) than that from the control rats (P < 0.001). Tomato lycopene complex prevented the rise of MDA and 8-isoprostane (P < 0.001). No measurable lycopene could be detected in the serum of the control and cisplatin-treated rats, whereas lycopene was observed in the serum of rats supplemented with tomato lycopene complex. Renal Bax protein expression was significantly higher in the cisplatin-treated rats than in the control rats, and tomato lycopene complex treatment significantly reduced Bax expression (P < 0.001). The expression of Bcl-2 was higher in tomato lycopene complex/cisplatin-treated rats than in the cisplatin-injected rats (P < 0.05). The expression of renal HSP60 and HSP70 was significantly lower in tomato lycopene complex + cisplatin-treated rats than in rats treated with cisplatin alone (P < 0.001). These results suggest that tomato lycopene complex has protective effects against cisplatin-induced nephrotoxicity and lipid peroxidation in rats. [ABSTRACT FROM AUTHOR]
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Titel: |
A Tomato Lycopene Complex Protects the Kidney From Cisplatin-Induced Injury via Affecting Oxidative Stress as Well as Bax, Bcl-2, and HSPs Expression.
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Autor/in / Beteiligte Person: | Dogukan, Ayhan ; Tuzcu, Mehmet ; Agca, Can ; Ali ; Gencoglu, Hasan ; Sahin, Nurhan ; Onderci, Muhittin ; Ozercan, İbrahim ; Hanifi ; İlhan, Necip ; Kucuk, Omer ; Sahin, Kazim |
Zeitschrift: | Nutrition & Cancer, Jg. 63 (2011-04-01), Heft 3, S. 427-434 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0163-5581 (print) |
DOI: | 10.1080/01635581.2011.535958 |
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