AUTOIMUNSKA TIREOIDNA BOLEST I POLIGLANDULARNE AUTOIMUNSKE BOLESTI. (Slovenian)
In: Medical Gazette / Medicinski Glasnik, Jg. 16 (2011-06-01), Heft 40, S. 9-18
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Zugriff:
Autoimmune polyglandular syndrome (APS) involves dysfunction of two or more endocrine glands, which is based on the autoimmune mechanism. Many authors in addition to the two main APS syndrome, involves the third stand in which autoimmune thyroid disease (ATD) is associated with other autoimmune diseases. APS type 1 occurs less frequently, starting in early childhood and the key is mutation in autoimmune regulator gene. Three major components characterize this syndrome: hypoparathyroidism, autoimmune adrenal insufficiency and mucocutaneous candidiasis. APS type 2 is associated with the HLA antigen system and basically is a disorder of CD4+ and CD25+ regulatory T-cells. The main components of the syndrome are: Addison's disease, ATD and type 1 diabetes mellitus. An important feature of APS is that the expression of components occurs in different time intervals, with each other long periods. ATD is more common than other autoimmune endocrine diseases and include Graves' disease, chronic autoimmune thyroiditis and postpartum thyroiditis. ATD associated with HLA class II genes and polymorphism of cytotoxic T-lymphocytes antigen 4. In basic there is disorder of cellular and humoral immunity, with auto-antibodies targeting tissue specific antigen and and present infiltration of mononuclear cells, predominantly lymphocytes in the affected tissue. The most common antibodies are thyroid peroxidase, thyroglobulin and TSH receptor antibodies. ATD is often associated with other endocrine (diabetes mellitus type 1, Addison's disease, autoimmune pituitary disease, hypoparathyreoidism, premature ovarian failure) and non-endocrine autoimmune diseases. Given the frequency of ATD is a legitimate screening of ATD in other autoimmune diseases, and not vice versa. Testing involves the determination of TPO antibodies and TSH to separate those with high risk of developing ATD and forecasts for further screening. [ABSTRACT FROM AUTHOR]
Autoimuni poliglandularni sindrom (PGA) podrazumeva disfunkciju dve ili više endokrinih žlezda, u čijoj osnovi je autoimuni mehanizam. Mnogi autori, pored dva osnovna PGA sindroma, izdvajaju treći koji podrazumeva autoimunu tireoidnu bolest (ATD) udruženu sa drugim autoimunim bolestima. PGA tip 1 se javlja ređe, sa početkom u ranom detinjstvu i ključna je mutacija autoimunog regulator-gena. Tri glavne komponente karakterišu ovaj sindrom: mukokutana kandi-dijaza, hipoparatireoidizam i autoimuna adrenalna insuficijencija. PGA tip 2 je povezan sa HLA sistemom antigena i u osnovi je poremećaj CD4+ i CD25+ regulatornih T-ćelija. Glavne komponente sindroma su Addisonova bolest, ATD i tip 1 diabetes mellitus. Bitna karakteristika PGA sindroma je da se ispoljavanje komponenti javlja u različitim vre-menskim intervalima sa višegodišnjim međusobnim periodima. ATD je mnogo češća od drugih autoimunih endokrinih bolesti i obuhvata Gravesovu bolest, hronični autoimuni tireoiditis i postpartalni tireoidi-tis. ATD asocira sa HLA klasom II gena i polimorfizmom citotoksičnih T-limfocitnih antigena 4. U osnovi je poremećaj celularnog i humoral-nog imuniteta sa stvaranjem autoantitela na tkivno specifični antigen i prisutnom infiltracijom mononuklearnih ćelija, dominantno limfocita u afektiranom tkivu. Najčešće su prisutna antitela na tireoidnu peroksidazu, tireoglobulin i TSH receptor. ATD je često udružena sa drugim endo-krinim (diabetes mellitus tip 1, Addisonova bolest, autoimune bolesti hipofize, hipoparatireoidizam, prevremena ovarijalna insuficijencija), ali i ne-endokrinim autoimunim bolestima. S obzirom na frekventnost ATD opravdan je skrining na ATD u okviru drugih autoimunih bolesti, a neobrnuto. Testiranje podrazumeva određivanje TPO antitela i TSH da bi se stratifikovali oni sa visokim rizikom za razvoj ATD i radi predviđanja daljeg skrininga. [ABSTRACT FROM AUTHOR]
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Titel: |
AUTOIMUNSKA TIREOIDNA BOLEST I POLIGLANDULARNE AUTOIMUNSKE BOLESTI. (Slovenian)
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Autor/in / Beteiligte Person: | Ljiljana, Todorović-Đilas ; Jovanka, Novaković-Paro ; Tijana, Ičin ; Ivana, Bajkin ; Branka, Kovačev-Zavišić |
Zeitschrift: | Medical Gazette / Medicinski Glasnik, Jg. 16 (2011-06-01), Heft 40, S. 9-18 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 1821-1925 (print) |
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