Clinical and autoantibody correlations in Orientals with systemic lupus erythematosus.
In: Annals of the Rheumatic Diseases, Jg. 47 (1988-11-01), Heft 11, S. 918-923
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Zugriff:
Serum samples from 94 patients with systemic lupus erythematosus (SLE) from a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence of antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell nuclear antigen (PCNA) (3%). Except for a higher prevalence of anti-SS-A(Ro), other autoantibodies were within the range reported from Western countries, indicating a high uniformity of autoantibody profiles in SLE in different countries. Patients with neuropsychiatric manifestations showed a higher plurality of antibodies per patient than patients without neuropsychiatric symptoms, 4.22 v 2.77. Patients with anti-Sm were more likely to have active lupus disease. There was no increased prevalence or specific type of autoantibody in those with renal manifestations. [ABSTRACT FROM PUBLISHER]
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Titel: |
Clinical and autoantibody correlations in Orientals with systemic lupus erythematosus.
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Autor/in / Beteiligte Person: | Boey, M L ; Peebles, C L ; Tsay, G ; Feng, P H ; Tan, E M |
Zeitschrift: | Annals of the Rheumatic Diseases, Jg. 47 (1988-11-01), Heft 11, S. 918-923 |
Veröffentlichung: | 1988 |
Medientyp: | academicJournal |
ISSN: | 0003-4967 (print) |
DOI: | 10.1136/ard.47.11.918 |
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