Low calcidiol levels and risk of progression of aortic calcification.
In: Osteoporosis International, Jg. 23 (2012-03-01), Heft 3, S. 1177-1182
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Summary: In this observational study, we found a positive relationship between low calcidiol levels and the risk of aortic calcification progression. A 10-ng/mL increase of calcidiol was associated with a decrease in the risk of progression by 44%. This figure was higher than that observed if we increased age by 10 years. Introduction: The aim of this study was to investigate the relationship between serum calcidiol levels and the onset and progression of aortic calcifications in a community-based sample of ambulatory subjects. Methods: Three hundred two men and women aged 50 and over underwent two lateral X-rays and were followed up for 4 years. Abdominal aortic calcifications were classified as absent, mild-moderate, and severe. The biochemical measurements of serum calcium, phosphorus, parathyroid hormone, total alkaline phosphatase, tartrate-resistant acid phosphatase, creatinine, calcidiol, calcitriol, and osteocalcin were determined. Subjects who had received anti-osteoporotic treatments were excluded from the analysis. Results: Subjects with progression of aortic calcifications had significantly lower serum calcidiol levels than those without progression. In the multivariate analysis, using the agreed upon serum levels for calcidiol (>30 ng/mL) as the reference, those subjects with calcidiol levels between 10 and 20 ng/mL showed a higher risk of progression of aortic calcification (odds ratio (OR) = 3.95; 95% confidence interval (CI) = 1.16 to 13.40). An even higher OR was observed in subjects with calcidiol values <10 ng/mL (OR = 4.10; 95% CI = 1.12 to 14.99). In addition, an increase by 1 ng/mL in osteocalcin levels was associated with a 17% reduction of the risk of aortic calcification progression. Conclusions: An increase by 10 ng/mL of calcidiol was associated with a decrease in the risk of aortic calcifications progression by 44%. This figure was even higher than that observed if we increased age by 10 years. Levels of calcidiol higher than 30 ng/mL seem to be desirable to reduce the progression of aortic calcification and to maintain bone turnover. [ABSTRACT FROM AUTHOR]
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Low calcidiol levels and risk of progression of aortic calcification.
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Autor/in / Beteiligte Person: | Naves-Díaz, M. ; Cabezas-Rodríguez, I. ; Barrio-Vázquez, S. ; Fernández, E. ; Díaz-López, J. ; Cannata-Andía, J. |
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Zeitschrift: | Osteoporosis International, Jg. 23 (2012-03-01), Heft 3, S. 1177-1182 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 0937-941X (print) |
DOI: | 10.1007/s00198-011-1550-0 |
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