Expression and clinical significance of tumor-associated macrophages and microvessel density in ameloblastomas. (English)
In: Shanghai Journal of Stomatology, Jg. 21 (2012-02-01), Heft 1, S. 57-61
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Zugriff:
PURPOSE: To investigate the expression and clinical significance of tumor-associated macrophages (TAMs) and microvessel density (MVD) in ameloblastomas (ABs). METHODS: The expression of TAMs (CD68) and MVD (CD34) was examined in 101 ABs and 26 oral, mucosa by streptavidin-peroxidase (SP) immunohistochemical technique and then quantified. The data were analyzed by Student's t test and Pearson correlation test using SPSS 11.5 software package. RESULTS: TAMs and MVD were mainly distributed within the stroma of ABS. TAMs count and MVD count were significantly higher in ABs compared with normal oral mucosa (P<0.05). Linear correlation analysis revealed a positive correlation between TAMs count and MVD count in ABs (r=0.428, P<0.05). CONCLUSION: Increased TAMs is associated with angiogenesis and may play an important role in invasive growth of ABs. Supported by National Natural Science Foundation of China (81072197) and the Youth Scientific Research Foundation of School of Stomatology, China Medical University (K101593-09-17). [ABSTRACT FROM AUTHOR]
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Expression and clinical significance of tumor-associated macrophages and microvessel density in ameloblastomas. (English)
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Autor/in / Beteiligte Person: | Ren, Mei-Si ; Wang, Jing ; Guo, Yan ; Zhong, Ming |
Zeitschrift: | Shanghai Journal of Stomatology, Jg. 21 (2012-02-01), Heft 1, S. 57-61 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 1006-7248 (print) |
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