Inhibition of Lysenin-induced Hemolysis by All-Lutein-E Derived from the Plant Dalbergia latifolia.
In: Planta Medica, Jg. 78 (2012-07-15), Heft 10, S. 957-961
serialPeriodical
Zugriff:
Lysenin is a pore-forming toxin derived from coelomic fluid of the earthworm Eisenia foetida. The model of lysenin-induced hemolysis includes the specific binding of lysenin to sphingomyelin, oligomerization of the pore proteins, and pore formation. Although themechanismof lysenin-induced hemolysis is unique, its precise mechanism of action and its inhibitors are poorly understood. In the present study, we screened for inhibitors of lysenin-induced hemolysis by using an optimized screening system and found a methanolic extract of Dalbergia latifolia leaves to be a potential candidate. After isolation and identification, all-E-lutein was identified as the hemolysis inhibitor with an effective dose of 0.025-2.5 ng/mL without any toxicity. The inhibition by all-E-lutein is likely to occur during the receptor binding and/ or pore-forming protein oligomerization. [ABSTRACT FROM AUTHOR]
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Titel: |
Inhibition of Lysenin-induced Hemolysis by All-Lutein-E Derived from the Plant Dalbergia latifolia.
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Autor/in / Beteiligte Person: | Niwa, Yuki ; Matsui, Chino ; Sukumwang, Neelanun ; Iinuma, Hironobu ; Ikeda, Yoko ; Koyano, Takashi ; Kovitayakorn, Taworn ; Simizu, Siro ; Umezawa, Kazuo |
Zeitschrift: | Planta Medica, Jg. 78 (2012-07-15), Heft 10, S. 957-961 |
Veröffentlichung: | 2012 |
Medientyp: | serialPeriodical |
ISSN: | 0032-0943 (print) |
DOI: | 10.1055/s-0031-1298538 |
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