Sesquiterpene Lactones from Inula hupehensis Inhibit Nitric Oxide Production in RAW264.7 Macrophages.
In: Planta Medica, Jg. 78 (2012-07-15), Heft 10, S. 1002-1009
serialPeriodical
Zugriff:
Phytochemical investigation of the aerial parts of Inula hupehensis Ling. led to the isolation and identification of 27 sesquiterpene lactones (1-27), including three new eudesmanolides (3-5), three new germacranolides (9-11), one new xanthanolide (16), two new carabrone derivatives (25-26), and 18 known sesquiterpene lactones. The structures were elucidated by extensive spectroscopic methods and comparison to previously reported spectroscopic data. All compounds were evaluated for their inhibitory effects against LPS-induced nitric oxide production in RAW264.7 macrophages, and compound 5 showed the strongest activity with the IC 50 value of 3.2 ± 0.4 µM. [ABSTRACT FROM AUTHOR]
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Titel: |
Sesquiterpene Lactones from Inula hupehensis Inhibit Nitric Oxide Production in RAW264.7 Macrophages.
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Autor/in / Beteiligte Person: | Qin, Jiang-Jiang ; Zhu, Jia-Xian ; Zeng, Qi ; Cheng, Xiang-Rong ; Zhang, Shou-De ; Jin, Hui-Zi ; Zhang, Wei-Dong |
Zeitschrift: | Planta Medica, Jg. 78 (2012-07-15), Heft 10, S. 1002-1009 |
Veröffentlichung: | 2012 |
Medientyp: | serialPeriodical |
ISSN: | 0032-0943 (print) |
DOI: | 10.1055/s-0031-1298621 |
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