The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer's Disease.
In: Dementia & Geriatric Cognitive Disorders, Jg. 34 (2012-09-15), Heft 2, S. 69-74
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Zugriff:
Background/Aim: There is growing consensus in the literature that inflammation plays a significant role in the pathophysiology of Alzheimer's disease (AD). The blood neutrophil-lymphocyte ratio (NLR) is a new, inexpensive and easily applicable marker of inflammation. The aim of this study was to investigate the association between NLR, as an inflammatory biomarker, and AD. Methods: 241 AD patients and 175 patients with normal cognitive function were evaluated in this study. Results: The mean ± SD NLR of AD patients was significantly higher than that of patients with normal cognitive function (3.21 ± 1.35 vs. 2.07 ± 0.74, p < 0.001, respectively). Receiver operating characteristic curve analysis suggested that the optimum NLR cutoff point for AD was 2.48 with 69.29% sensitivity, 79.43% specificity, 82.30% positive predictive values and 65.30% negative predictive values. Logistic regression analysis showed that elevated NLR (OR: 4.774, 95% CI: 2.821-8.076, p < 0.001) was an independent variable for predicting AD. Conclusion: Elderly people with AD have higher NLR than healthy controls. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of AD. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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The Evaluation of Neutrophil-Lymphocyte Ratio in Alzheimer's Disease.
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Autor/in / Beteiligte Person: | Kuyumcu, Mehmet Emin ; Yesil, Yusuf ; Oztürk, Zeynel Abidin ; Kizilarslanoğlu, Cemal ; Etgül, Sezgin ; Halil, Meltem ; Ulger, Zekeriya ; Cankurtaran, Mustafa ; Arıoğul, Servet |
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Zeitschrift: | Dementia & Geriatric Cognitive Disorders, Jg. 34 (2012-09-15), Heft 2, S. 69-74 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 1420-8008 (print) |
DOI: | 10.1159/000341583 |
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