Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer.
In: Cancer Investigation, Jg. 19 (2001-03-01), Heft 3, S. 225-233
Online
academicJournal
Zugriff:
This study evaluated mitoxantrone and paclitaxel combination chemotherapy in the treatment of patients with metastatic breast cancer. Thirty-seven patients who had developed progressive disease after prior chemotherapy were treated with mitoxantrone (14 mg/m2) and paclitaxel (150 mg/m2) every 21 days for a maximum of six cycles. The most frequent grade 3 or 4 nonhematological toxicities were fever and nausea. Grade 4 neutropenia occurred in 71% of patients. Cardiotoxicity occurred in 2 patients, both of whom had previously received doxorubicin. Objective response was achieved in 35% of patients (5% complete response and 30% partial response) and 41% had stable disease. Median time to disease progression and median survival were 6 and 12 months, respectively. The percent of patients with an objective response was not different for those who had received prior doxorubicin or had chemotherapy in the preceding 6 months. This regimen appears to be effective and well tolerated as salvage therapy and merits further evaluation. [ABSTRACT FROM AUTHOR]
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Titel: |
Mitoxantrone and paclitaxel combination chemotherapy in metastatic breast cancer.
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Autor/in / Beteiligte Person: | Harvey, Jimmie ; Cantrell, James ; Campbell, Mark ; Cartmell, Alan ; Urba, Walter ; Modiano, Manuel ; Schuster, Michael ; Rubin, Abbe ; Newcomb, Terry ; Ghalie, Richard ; Harvey, J ; Cantrell, J Jr ; Campbell, M ; Cartmell, A ; Urba, W ; Modiano, M ; Schuster, M ; Rubin, A ; Newcomb, T ; Ghalie, R |
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Zeitschrift: | Cancer Investigation, Jg. 19 (2001-03-01), Heft 3, S. 225-233 |
Veröffentlichung: | 2001 |
Medientyp: | academicJournal |
ISSN: | 0735-7907 (print) |
DOI: | 10.1081/CNV-100102548 |
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