Clinical trials using stem cells. (English)

In animal models, the results of studies have shown the efficacy of stem cells in repairing tissues and curing different diseases; however, in humans the effectiveness of cell therapy has proven in blood disorders and the immune system. Different phases of clinical trials on the other uses of stem cells are also underway. In this study, the published results of the clinical trials conducted were evaluated. For this purpose, at first, the stages of clinical trials, the guidelines for the clinical translation of stem cells, and the number of clinical trials on the use of stem cells were studied; then, the results of clinical trials using different kinds of stem cells were assessed. The data were obtained by selecting the key word of "stem cells" in the public clinical trials database "http://www.clinicaltrials.gov" and using several review articles in the field of clinical trials of stem cells. This report demonstrates the safety of stem cell therapy in the primary phases of clinical trials; however, for the efficacy of the therapy to be established the final phases of clinical trials need to be accomplished and evaluated. [ABSTRACT FROM AUTHOR]

Copyright of Scientific Journal of Iranian Blood Transfusion Organization is the property of Iranian Blood Transfusion Organization Research Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)