Value of apparent diffusion coefficient (ADC) in evaluating response of carcinoma of the cervix treated with chemoradiotherapy.
In: South African Journal of Radiology, Jg. 17 (2013-03-01), Heft 1, S. 11-15
Online
academicJournal
Zugriff:
Objective. To determine whether the apparent diffusion coefficient (ADC) value obtained by diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a reliable detector of response of carcinoma of the cervix treated with chemoradiotherapy, compared with conventional T2-weighted MRI. Design. A prospective cohort study was performed. Setting. Department of Oncology, Universitas-National Hospital Complex, Bloemfontein. Subjects. Seventeen women with advanced cervical cancer, FIGO staging IIB - IVB, were selected for chemoradiation. Outcome measures. Patients underwent pelvic MRI before therapy, 14 days after onset of therapy, and in the last week of treatment (5th/6th week). Axial and sagittal conventional T2 was followed by DW-MRI in the axial plane from which a tumour region of interest (ROI) was manually drawn to calculate ADC values using b-values of 500 and 1 000 s/mm². Results. ADC values for cervical carcinoma increased after treatment with chemoradiation. The most significant observation was seen 14 days after treatment was started. The mean ADC value increased with 20% (b=500 s/mm²) and 24% (b=1 000 s/mm2) (statistically significant, p<0.05) compared with a decrease in tumour size of only 8%, which was not statistically significant (p=0.075). Responders showed a larger change in ADC values than non-responders. Conclusion. The study showed considerable promise in the ability of ADC to identify early tumour response to therapy. DW-MRI is a non-invasive functional imaging technique that may in future change management in oncology by early identification of non-responders, hence avoiding unnecessary treatment. [ABSTRACT FROM AUTHOR]
Copyright of South African Journal of Radiology is the property of African Online Scientific Information System PTY LTD and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Value of apparent diffusion coefficient (ADC) in evaluating response of carcinoma of the cervix treated with chemoradiotherapy.
|
---|---|
Autor/in / Beteiligte Person: | le Roux, A. ; Gebremariam, F. ; Harmse, W. |
Link: | |
Zeitschrift: | South African Journal of Radiology, Jg. 17 (2013-03-01), Heft 1, S. 11-15 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 1027-202X (print) |
DOI: | 10.4102/sajr.v17i1.203 |
Schlagwort: |
|
Sonstiges: |
|