Predicting Sjögren’s syndrome in patients with recent-onset SLE.
In: Rheumatology, Jg. 52 (2013-08-01), Heft 8, S. 1438-1442
Online
academicJournal
Zugriff:
Objective. To determine the prevalence of SS in a cohort of recent-onset SLE patients and evaluate the clinical and immunological variables that may identify SLE patients prone to develop SS.Methods. A total of 103 patients participating in a prospective cohort of recent-onset SLE were assessed for fulfilment of the American European Consensus Group criteria for SS using a three-phase approach: screening (European questionnaire, Schirmer-I test and wafer test), confirmation (fluorescein staining test, non-stimulated whole-salivary flow and anti-Ro/La antibodies) and lip biopsy. Anti-Ro/SSA and anti-La/SSB antibodies and RF were measured at entry into the cohort and at SS assessment.Results. Ninety-three females and 10 males were included. Mean age at lupus diagnosis was 25.9 ± 8.9 years, and lupus duration at SS assessment was 30.9 ± 9.1 years. SS was diagnosed in 19 (18.5%) patients, all female, and the patients were older at SLE diagnosis than patients without SS (30.8 ± 9.3 vs 24 ± 8.8 years, P = 0.004). Anti-Ro/SSA antibody was more common in SLE-SS patients (84% vs 55%, P = 0.02, LR + 1.53, 95% CI 1.14, 2.04). In the multivariate analysis, age ≥25 years and anti-Ro/SSA antibodies at SLE diagnosis were identified as predictors of SLE-SS, while the absence of anti-Ro/SSA, anti-La/SSB and RF seems to be protective (LR− 0.14, 95% CI 0.02, 0.95).Conclusion. The overlap of SLE and SS occurs in almost one-fifth of SLE patients and presents early during its evolution. SLE onset at age ≥25 years plus the presence of anti-Ro/SSA antibody at diagnosis are useful predictors, while the absence of anti-Ro/SSA, anti-La/SSB and RF identifies patients at lowest risk. [ABSTRACT FROM PUBLISHER]
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Predicting Sjögren’s syndrome in patients with recent-onset SLE.
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Autor/in / Beteiligte Person: | Hernández-Molina, Gabriela ; Zamora-Legoff, Tatiana ; Romero-Díaz, Juanita ; Nuñez-Alvarez, Carlos A. ; Cárdenas-Velázquez, Francisco ; Hernández-Hernández, Carlos ; Calderillo, Maria Luisa ; Marroquín, Martha ; Recillas-Gispert, Claudia ; Ávila-Casado, Carmen ; Sánchez-Guerrero, Jorge |
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Zeitschrift: | Rheumatology, Jg. 52 (2013-08-01), Heft 8, S. 1438-1442 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 1462-0324 (print) |
DOI: | 10.1093/rheumatology/ket141 |
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