Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study.
In: Osteoporosis International, Jg. 25 (2014-03-01), Heft 3, S. 1123-1129
Online
academicJournal
Zugriff:
Summary: Postmenopausal estrogen decline is implicated in several age-related physical and psychological changes in women, including decreases in perceived quality of life. The phytoestrogen genistein at a dose of 54 mg daily in osteopenic postmenopausal women after 2 years implies an improvement on quality of life and depression symptoms. Introduction: Postmenopausal estrogen decline is implicated in several age-related physical and psychological changes in women, including decreases in perceived quality of life (QoL). A number of trials with hormone therapy showed beneficial effects of the intervention on quality of life parameters. However, because of known or suspected serious side effects of conventional hormone therapy, there is a need for alternatives. Methods: We conducted a double-blind randomized placebo-controlled trial using the isoflavone genistein, 54 mg, or placebo for 2 years. In this trial, we recruited 262 postmenopausal women aged 49 to 67 years. Results: At baseline, after 1 year, and at final visit, participants filled in the Short Form of 36 questions (SF-36) and the Zung Self-rating Depression Scale (ZSDS). For the placebo group, scores on all dimensions of the SF-36 decreased after 1 and 2 years. The genistein group showed increases on all dimensions of the SF-36 at the end of the study. There were, however, statistically significant differences in changes of scores between the two intervention groups. For the ZSDS, similarly, significant differences were found between groups. Conclusion: In conclusion, the findings of this randomized trial showed that genistein improves quality of life (health status, life satisfaction, and depression) in osteopenic postmenopausal women. [ABSTRACT FROM AUTHOR]
Copyright of Osteoporosis International is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study.
|
---|---|
Autor/in / Beteiligte Person: | Atteritano, M. ; Mazzaferro, S. ; Bitto, A. ; Cannata, M. ; D'Anna, R. ; Squadrito, F. ; Macrì, I. ; Frisina, A. ; Frisina, N. ; Bagnato, G. |
Link: | |
Zeitschrift: | Osteoporosis International, Jg. 25 (2014-03-01), Heft 3, S. 1123-1129 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0937-941X (print) |
DOI: | 10.1007/s00198-013-2512-5 |
Schlagwort: |
|
Sonstiges: |
|