Impact of therapy and disease-related symptoms on health-related quality of life in patients with follicular lymphoma: results of the population-based PHAROS-registry.
In: European Journal of Haematology, Jg. 93 (2014-09-01), Heft 3, S. 229-238
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Zugriff:
Objectives The increasing number of longer living patients with follicular lymphoma ( FL) and serious side effects of treatment urged us to study the health-related quality of life ( HRQo L) and persistent (treatment-related) symptoms in unselected patients after different treatment modalities and compare HRQo L of patients with a normative population. Methods The population-based Eindhoven Cancer Registry was used to select patients diagnosed with FL during 2004-2010. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 ( EORTC QLQ- C30) was completed twice, with a 1-yr interval. This questionnaire was also completed by an age- and sex-matched normative population ( N = 580). Detailed data on treatment were extracted from the cancer registry and Population-based HAematological Registry for Observational Studies ( PHAROS). Results Of the 181 patients who were invited, 148 responded (82%, T1). Patients treated with immunochemotherapy reported clinically relevant higher mean fatigue scores than those who underwent radiotherapy ( P = 0.02). No differences were observed on the other HRQo L scales between treatment groups. Mean HRQo L scores were worse for FL patients treated with immunochemotherapy compared with a normative population ( P < 0.01). A quarter to 50% of patients persistently reported to be slowed down, lethargic, or persistently worried about future health or was limited in social activities. Subsequently, patients reporting these symptoms/worries had a lower global health status/ HRQo L. Conclusion Alertness for persistent symptoms that occur during and after treatment of FL patients is needed and may help to avoid lasting negative influence on their HRQo L. [ABSTRACT FROM AUTHOR]
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Impact of therapy and disease-related symptoms on health-related quality of life in patients with follicular lymphoma: results of the population-based PHAROS-registry.
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Autor/in / Beteiligte Person: | Oerlemans, Simone ; Issa, Djamila E. ; Broek, Esther C. ; Nijziel, Marten R. ; Coebergh, Jan Willem W. ; Mols, Floortje ; Poll‐Franse, Lonneke V. |
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Zeitschrift: | European Journal of Haematology, Jg. 93 (2014-09-01), Heft 3, S. 229-238 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0902-4441 (print) |
DOI: | 10.1111/ejh.12335 |
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