Clinical Efficacy of Antioxidant Therapy for Herpes Simplex Virus Keratitis. (English)
In: Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, Jg. 35 (2014-12-01), Heft 12, S. 134-137
academicJournal
Zugriff:
Objective To study the clinical efficacy of antioxidant therapy using edaravone and ganciclovir for herpes simplex virus keratitis. Methods 65 patients with herpes simplex virus keratitis were randomly divided into control and treatment groups. The control group was given ganciclovir treatment, the treatment group was given edaravone on the basis of ganciclovir. Before treatment and after treatment, the ulcer length and clinical efficacy were recorded, malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were also detected. Results After treatment for 5 days abd 10 days, the length of ulcer was significantly different to that before treatment (P < 0.05), and the symptoms of the treatment group was significantly improved as compared to the control group (P < 0.05). After treatment, the clinical efficacy of treatment group was significantly better than the control group (P < 0.05). After treatment for 5 days, MDA levels in the treatment group were significantly decreased as compared to before treatment and the control group (P < 0.05), SOD and GSH were also significantly higher than before treatment (P < 0.05). After treatment for 10 days, MDA, SOD and GSH were significantly improved as compared to before treatment and the control group (P < 0.05). Conclusion Edaravone antioxidant therapy can improve the oxidative stress status of patients with herpes simplex virus and help these patients rehabilitate early. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Clinical Efficacy of Antioxidant Therapy for Herpes Simplex Virus Keratitis. (English)
|
---|---|
Autor/in / Beteiligte Person: | Hai-xia, BIAN ; Hong-bing, ZHANG |
Zeitschrift: | Journal of Kunming Medical University / Kunming Yike Daxue Xuebao, Jg. 35 (2014-12-01), Heft 12, S. 134-137 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 2095-610X (print) |
Schlagwort: |
|
Sonstiges: |
|