Researchers Submit Patent Application, "Differential Knockout Of An Allele Of A Heterozygous Rhodopsin Gene", for Approval (USPTO 20230173105).
In: Health & Medicine Week, 2023-06-30, S. 2788-2788
serialPeriodical
Zugriff:
"According to some embodiments of the present invention, there is provided a method for inactivating a mutant Rho allele in a cell, the method comprising delivering to the cell a composition comprising an RNA molecule comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and a CRISPR nuclease. A method for editing a mutant Rhodopsin (Rho) allele in a human cell, the method comprising delivering a composition comprising a) an RNA molecule comprising a guide sequence portion consisting of 17-24 nucleotides and targeting a sequence in the mutant Rho allele linked to SNP ID No. rs7984 based on the National Center for Biotechnology Information Database of Single Nucleotide Polymorphisms (dbSNP); and b) a CRISPR nuclease, to a human cell that has a mutant Rho allele and a functional Rho allele, such that the mutant Rho allele is edited.". [Extracted from the article]
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Titel: |
Researchers Submit Patent Application, "Differential Knockout Of An Allele Of A Heterozygous Rhodopsin Gene", for Approval (USPTO 20230173105).
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Zeitschrift: | Health & Medicine Week, 2023-06-30, S. 2788-2788 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6459 (print) |
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