New Osteosarcomas Research from University of Catania Described (Abstract 1700: Clonal emergence of resistance to methotrexate in osteosarcoma barcoded PDX cells).
In: Cancer Weekly, 2023-06-27, S. 557-557
serialPeriodical
Zugriff:
Our observations show that [3H] MTX uptake was affected differently in PDXs and derived clones, highlighting a wide variability in MTX transport, possibly due to different mutations in the reduced folate carrier (RFC) gene in different clones. Keywords: Antimetabolites; Antineoplastics; Antipsoriatics; Antirheumatics; Cancer; Cell Line; Drugs and Therapies; Genetics; Health and Medicine; Methotrexate Therapy; Oncology; Osteosarcomas; Pharmaceuticals EN Antimetabolites Antineoplastics Antipsoriatics Antirheumatics Cancer Cell Line Drugs and Therapies Genetics Health and Medicine Methotrexate Therapy Oncology Osteosarcomas Pharmaceuticals 557 557 1 06/26/23 20230627 NES 230627 2023 JUN 27 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Weekly -- New research on osteosarcomas is the subject of a new report. We have previously shown in our barcoded PDX models that, by applying selective pressure with methotrexate (MTX) IC95 treatment, a clonal subpopulations more resistant to MTX emerges.". [Extracted from the article]
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Titel: |
New Osteosarcomas Research from University of Catania Described (Abstract 1700: Clonal emergence of resistance to methotrexate in osteosarcoma barcoded PDX cells).
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Zeitschrift: | Cancer Weekly, 2023-06-27, S. 557-557 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
ISSN: | 1071-7218 (print) |
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