Researcher at University of Wisconsin School of Medicine and Public Health Releases New Data on Head and Neck Cancer (Stress Keratin 17 Is a Predictive Biomarker Inversely Associated with Response to Immune Check-Point Blockade in Head and Neck...).

Our group previously showed that stress keratin 17 (CK17) suppresses macrophage-mediated CXCL9/CXCL10 chemokine signaling involved in attracting activated CD8+ T cells into tumors, correlating with decreased response rate to pembrolizumab-based therapy in a pilot cohort of ICB-treated HNSCC (n = 26)." Keywords: Biomarkers; Biopolymers; Cancer; Carcinomas; Cytoskeletal Proteins; Diagnostics and Screening; Drugs and Therapies; Head and Neck Cancer; Health and Medicine; Immunologic Agents; Immunotherapy; Intermediate Filament Proteins; Keratin-17; Keratins; Monoclonal Antibodies; Oncology; Pembrolizumab Therapy; Pharmaceuticals; Proteins; Scleroproteins; Squamous Cell Carcinoma; Type I Keratins EN Biomarkers Biopolymers Cancer Carcinomas Cytoskeletal Proteins Diagnostics and Screening Drugs and Therapies Head and Neck Cancer Health and Medicine Immunologic Agents Immunotherapy Intermediate Filament Proteins Keratin-17 Keratins Monoclonal Antibodies Oncology Pembrolizumab Therapy Pharmaceuticals Proteins Scleroproteins Squamous Cell Carcinoma Type I Keratins 829 829 1 10/24/23 20231024 NES 231024 2023 OCT 24 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Research findings on head and neck cancer are discussed in a new report. [Extracted from the article]

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