A FAMILIAL TANDEM TRANSLOCATION (15;21)(q11;q22) IN A CASE OF DOWN'S SYNDROME.

The article discusses about a case study of a familial tandem translocation in a patient with Down's syndrome. The most usual form of translocation in Down's syndrome is of the centric fusion type. The purpose of the present report is to give a clinical and cytogenetic description of a familial tandem translocation 15/21 with trisomy 21 in one of the translocation carriers. The loss of a centromere and the short arms, with any satellites, in a carrier of a balanced translocation of centric fusion type does not appear to manifest itself in the phenotype. This is probably because these portions of the chromosomes contain little or no important genetic information.