Study Findings from Justus-Liebig-University Provide New Insights into 17-Ketosteroids (Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase).
In: Genomics & Genetics Weekly, 2024-02-16, S. 1708-1708
serialPeriodical
Zugriff:
A new report discusses research findings on 17-ketosteroids, which are involved in the synthesis of estrogens. The study, conducted at Justus-Liebig-University in Germany, focuses on the enzyme aromatase and its role in converting testosterone and androstenedione into estrogens. The researchers discovered novel isoforms of the CYP19 gene that are characterized by specific mutations in the transmembrane helix and catalytic domain of the enzyme. These mutations were found to affect the enzyme's activity and substrate preference. The study provides structural insights into the catalytic differences of the mutant isoforms. [Extracted from the article]
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Titel: |
Study Findings from Justus-Liebig-University Provide New Insights into 17-Ketosteroids (Charged Amino Acids in the Transmembrane Helix Strongly Affect the Enzyme Activity of Aromatase).
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Zeitschrift: | Genomics & Genetics Weekly, 2024-02-16, S. 1708-1708 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6467 (print) |
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