Study Data from Wayne State University Update Understanding of Spinocerebellar Ataxias (Phenotypic Defects From the Expression of Wild-type and Pathogenic Tata-binding Proteins In New Drosophila Models of Spinocerebellar Ataxia Type 17).
In: Gene Therapy Weekly, 2024-03-08, S. 3197-3197
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Zugriff:
A study conducted by researchers at Wayne State University in Detroit, Michigan, explores Spinocerebellar Ataxia Type 17 (SCA17), a neurodegenerative disease caused by abnormal CAG/CAA expansion in the TATA box-binding protein (TBP). The study introduces two new Drosophila models that express human TBP with polyQ repeats, one in the wild-type range and the other in the SCA17 patient range. The researchers found that the expression of TBP has age- and tissue-specific effects on neurodegeneration, with the SCA17 protein having more severe effects. These models provide valuable insights into SCA17 pathology and potential therapeutic targets. The study was supported by the National Institutes of Health (NIH) in the United States. [Extracted from the article]
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Titel: |
Study Data from Wayne State University Update Understanding of Spinocerebellar Ataxias (Phenotypic Defects From the Expression of Wild-type and Pathogenic Tata-binding Proteins In New Drosophila Models of Spinocerebellar Ataxia Type 17).
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Zeitschrift: | Gene Therapy Weekly, 2024-03-08, S. 3197-3197 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1078-2842 (print) |
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