Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes (Updated April 17, 2024).
In: Blood Weekly, 2024-05-20, S. 85-85
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Zugriff:
This article discusses a study on the biological and genetic factors that affect glycolysis in red blood cells (RBCs) during storage and transfusion. The study found associations between donor age, sex, ethnicity, and levels of glycolytic metabolites in RBCs. Genetic polymorphisms in genes encoding phosphofructokinase 1, platelet, hexokinase 1, and ADP-ribosyl cyclase 1 and 2 were also linked to glycolysis in RBCs. The study further showed that ATP levels and breakdown were associated with hemolysis in vitro and in vivo, impacting transfusion outcomes. However, it is important to note that this study has not yet undergone peer review. [Extracted from the article]
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Titel: |
Biological and Genetic Determinants of Glycolysis: Phosphofructokinase Isoforms Boost Energy Status of Stored Red Blood Cells and Transfusion Outcomes (Updated April 17, 2024).
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Zeitschrift: | Blood Weekly, 2024-05-20, S. 85-85 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1065-6073 (print) |
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