Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration. (Updated April 17, 2024).
In: Blood Weekly, 2024-05-20, S. 462-462
serialPeriodical
Zugriff:
According to a preprint abstract from biorxiv.org, the role of Sarm1 in peripheral nervous system (PNS) regeneration in mammals is unknown. However, the study found that Sarm1 is not necessary for the activation of neuron-intrinsic growth programs or axonal growth into a nerve crush site. In the distal nerve, Sarm1 is required for the timely induction of the Schwann cell repair response, nerve inflammation, myelin clearance, and regeneration of sensory and motor axons. The study also showed that in Sarm1-/- mice, regenerated fibers exhibit reduced axon caliber, defective nerve conduction, and delayed recovery of motor function. The findings suggest that Sarm1 is not necessary for the activation of neuron intrinsic growth programs, but it is required for the orchestration of cellular programs that facilitate rapid axon extension in the distal nerve. [Extracted from the article]
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Titel: |
Sarm1 is not necessary for activation of neuron-intrinsic growth programs yet required for the Schwann cell repair response and peripheral nerve regeneration. (Updated April 17, 2024).
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Zeitschrift: | Blood Weekly, 2024-05-20, S. 462-462 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1065-6073 (print) |
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